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1 Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes the loss of upper and lower motor neurons, ALS patients mainly are with muscle weakness, stiffness and atrophy

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Enzymes, such as glutaminase C (GAC) and glutaminase 2 (GLS2), which facilitate the conversion of glutamine-to-glutamate, are pivotal in the glutamine dependency observed in cancer cells 44

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