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Reduced claudin-5 expression leads to a greater barrier permeability, and reduced occludin expression is known to alter calcium fluxes into the brain, both reducing BBB integrity [10]

Interestingly, the effects of autophagy gene knockout differed based on the genetic background, especially regarding crucial tumor suppressors like APC and Tp53

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Glutathione is a compound found in nearly every cell and plays a role in maintaining cellular balance, supporting the bodys response to everyday environmental stressors, and promoting overall wellness

This leads to an impaired conversion of primary to secondary BAs, markedly shifting the overall BA composition