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Considering the high rate of SARS-CoV-2 transmission and that there is no known cure for this disease at present, identifying vulnerable populations will be crucial for taking measures to protect those who are at increased risk of infection or of severe disease from COVID-19 ( Alcohol consumption and cigarette smoking (CS) are two known risk factors in many diseases including respiratory infections ( Materials and Methods Study Design and Participants Our multi-center study was performed in the four largest hospitals designated for COVID-19 patients in Wuhan