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These molecules act as signaling messengers, providing communication between cells, supporting healing processes, and complementing the broader effects of cell-based interventions

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In 1948, Rathbun first described the disease as hypophosphatasia in an infant, presented with severe bone loss, seizures, and low levels of alkaline phosphatase tissue and blood, who died of tonic epilepsy at 2 months of age [39]

Additionally, three studies with pre-exercise design reported effects on the immune system, cytokine production, and T-cell response