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It is still not known whether donor astrocytes could be negatively influenced by the toxic host environment and by activation signals from degenerating motor neurons, and if healthy transplanted cells can turn into aberrant astrocytes

Moreover, blood L-phenylalanine levels dropped below the therapeutic threshold of 360 M/L after the second injection

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Carpenter CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS, Cantley LC

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