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Reprod Sci 16, 10401051

They revealed that cells with down-regulated GPX4 expression were more susceptible to ferroptosis, while the overexpression of GPX4 inhibits ferroptosis (Yang et al., 2014)

M(heme) macrophage polarization is driven by extracellular heme, and similarly to that of M(Hb) this subset is protected from oxidative stress and lipid accumulation (107)