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Originally developed at Monash University as part of research into the lipolytic domain of hGH, AOD-9604 retains many of the fat-mobilising characteristics of full-length growth hormone while lacking the broader growth-promoting and insulin-resistance effects associated with the parent molecule

FDA-approved GLP-1 peptides such as semaglutide and tirzepatide have the strongest safety data, with GoodRx confirming these prescription-only medications are safe and effective when used as directed, a status consistent with the FDA's approval of tirzepatide for chronic weight management

Conflict of interest NWCJvdD has received research support from Janssen Pharmaceuticals, AMGEN, Celgene, Novartis, Cellectis and BMS, and serves on advisory boards for Janssen Pharmaceuticals, AMGEN, Celgene, BMS, Sanofi, Takeda, Roche, Novartis, Bayer, Adaptive, Galapagos, Kite Pharma, Merck, Pfizer, AbbVie, and Servier

CNX-010-49, is another selective tissue-acting 11-HSD1 inhibitor under investigation