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demonstrated that copper ionophore disulfiram (DSF) could selectively target HCC cells through iron death mechanisms, and the combination of DSF/Cu with sorafenib, which inhibits nuclear factor erythroid 2-related factor 2 (NRF2) function, may provide a promising synergistic strategy to overcome drug resistance and enhance tumor treatment (160)

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Furthermore, as specified above, MNs are not isolated units and also rely on glial cells for antioxidant protection through the NRF2/ARE signalling

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Notably, transplantation of fecal matter from normal mice into HU mice ameliorated the damage inflicted upon the intestinal barrier