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It has also been linked to inflammation, with several studies suggesting that high levels of methionine intake may contribute to chronic inflammation

Several approaches evaluated the inhibition of TGF- signaling in glioma (www.clinicaltrials.gov) using antibodies, antisense oligonucleotides, ligand traps or TGF- receptor kinase inhibitors 29,45

Bloodbrain barrier and BCB are guarding systems of the brain formed mainly by endothelial cells, which separate the central nervous system (CNS) from the general circulatory system of the body, protecting the brain from toxic metabolites and pathogens (Zenaro et al., 2017)

Thus, the inhibition of glycolysis may be another anti-tumor mechanism of ASP