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Both MMF and fumarate are believed to be responsible for the primary therapeutic effects of DMF through activation and inhibition of the transcription factors, Nrf2 ( via the agonism of the hydroxycarboxylic acid receptor 2 ( in vitro and in vivo immunologic actions of DMF ( in vitro causes a rise in the concentration of succinate ( in vivo by using global metabolomics profiling of blood plasma of patients with relapsing-remittent multiple sclerosis treated for 6 weeks with DMF

Chen SQ, Wang ZS, Ma YX, Zhang W, Lu JL, Liang YR, Zheng XQ (2018) Neuroprotective effects and mechanisms of tea bioactive components in neurodegenerative diseases

Randomization was stratified by HbA1c of less than 85% at screening (yes or no) and country (Japan

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Among these, the key ones were the genes encoding albumin (ALB), protein kinase B (AKT) serine/threonine kinase 1 (AKT1), and tumor protein p53 (TP53), and the phosphatidylinositol 3-kinase (PI3K)/AKT signaling pathway was a critical pathway involved