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[5]Current Patent Assignee: MERCK SHARP DOHME - WO2022/10828, 2022, A1

This may be true of individuals with BHMT down-regulations, specifically in individuals who are ++ or +/- the following mutations: BHMT 1 BHMT 2 BHMT 4 BHMT 8 Based upon recent observations, CBS pathway up-regulations will result in a higher production of ammonia, urinary sulfates, as well as decreases in Glutathione (GSH) synthesis, and/or possibly imbalances in GSHs redox (reduction/oxidation) ratio

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Pharmacological approach using doxycycline and tocopherol in rotenone induced oxidative stress, neuroinflammation and Parkinsons like symptoms

While this approach does not allow for quantitative aggregation of results, it provides a narrative framework for interpreting the effects of different VR protocols