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Descending control of pain

erinaceus is marketed as a dietary supplement rather than a pharmaceutical product, often requiring less stringent safety and efficacy data

Many of these agents, including peptide-based and hydrophobic small molecules, exhibit poor CNS bioavailability, necessitating advanced delivery systems such as nanoparticles, convection-enhanced delivery, or BBB permeabilizing strategies [113, 153]

Taylor A, Robson A, Houghton BC, Jepson CA, Ford WC, Frayne J (2013) Epididymal specific, selenium-independent GPX5 protects cells from oxidative stress-induced lipid peroxidation and DNA mutation

Nature 624 (7992), 645652