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For more on these pathways, 3 Phases of Detoxification offers a broader look at the bodys detox support systems

GPX-4s decreased activity, followed by increased activity of ACSL4, leads to iron accumulation and induction of ferroptosis (He and Shi 2023)

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Furthermore, HMGA1 is a positive regulator of IGF1, IGF1R, IGFBP1 and IGFBP3 ( A miRNA expression profiling in both sporadic GH-secreting pituitary adenomas and non-functioning pituitary adenomas highlighted that miR-107, a miRNA involved in many cancer types, was described to be upregulated

Conversely, astrocytes also have beneficial roles during PD progression [21-22]