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Key Research Findings HGF/c-Met Receptor Activation Facilitates dimerization of the hepatocyte growth factor receptor, activating downstream PI3K/Akt and MAPK/ERK signaling cascades involved in neuronal survival Synaptogenic Activity Preclinical research demonstrated promotion of new dendritic spine formation and synaptic connections in hippocampal neurons at picomolar concentrations Cognitive Research Animal studies showed enhanced performance in spatial learning and memory tasks (Morris water maze, radial arm maze) in models of cognitive impairment Blood-Brain Barrier Penetration Unlike parent angiotensin IV peptides, Dihexa was engineered for oral bioavailability and CNS penetration Neurotrophic Factor Modulation Research suggests amplification of endogenous HGF signaling rather than direct receptor activation, potentiating existing neurotrophic pathways Specifications Reported Side Effects in Research Limited safety data

IL-1 and IL-6 also induce changes in the TJs [79, 80]