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The method of item 89, wherein the scaffold reactive groups are selected from carboxylic acids, alcohols, thiols, aldehydes, ketones, amides, imides, amines, azo, diazo, azido, hydrazines, carbamates, esters, thioesters, cyanides, ethers, isocyanates, isothiocyanates, sulfides, nitriles, nitrites, nitrates, nitro, peroxides, phosphates, thiophosphates, sulfides, epoxides, anhydrides, halides, acid halides, organometallics, nitrides, phosphides, carbides, and silicides

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