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Sep 2021;128:233-243

These biochemical relationships demonstrate that folate availability and MTHFR activity define the upper limit for DNA and histone methylation, providing a mechanistic bridge to the epigenetic phenotypes described in autoimmune diseases (95-97,99)

References Pollak, M

3.1 Dietary effect on GM It is well known, that the hosts diet is the key nutrient source for the GM and will therefore have a profound effect on GM density, composition and diversity (Ring et al., 2016), and can lead to significant changes in the hosts gut function