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Description

Microdeletion and IGF2 loss of imprinting in a cascade causing Beckwith-Wiedemann syndrome with Wilms' tumour

D.CousinS

About Ipamorelin peptide Peptide Type: GH secretagogue analog Receptor Target: GHSR-1a (Ghrelin receptor) Sequence: Synthetic pentapeptide Signaling Pathways: Gq/PLC Ca release

Native IGF-1 has 10-20 minute half-life, strong IGFBP binding limiting bioavailability, primarily local autocrine/paracrine actions, and rapid clearance

Ipamorelin showed dose-proportional pharmacokinetics with a terminal half-life of about 2 hours and a single discrete GH pulse peaking near 0.67 h in healthy human volunteers (Gobburu et al., Pharmaceutical Research, 1999)