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For instance, rats receiving baclofen showed reduced hyper-locomotion caused by acute alcohol administration (Besheer et al., 2004), and reduced anxiety-like behavior and tremors following chronic alcohol withdrawal (Knapp et al., 2007)

NO is believed to increase PGC-1 activity via the activation of the GC pathway or the 5-AMP-activated protein kinase pathway ( FIGURE 3 As previously discussed, NO activates GC and the subsequent production of cGMP, which modulates muscle contractile function

doi: 10.1016/S0021-9258(18)34941-X 95 OvernellJ.GoodM.VaakM

2.7 Western blot The cellular and tissue samples were homogenized on ice using RIPA Lysis buffer supplemented with protease inhibitors (Beyotime)

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