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Mice were sacrificed 24 hours post-LPS administration

The importance of glia in dealing with stress

5.1.2 Hypothalamuspituitaryadrenal (HPA) axis regulation The hypothalamuspituitaryadrenal (HPA) axis is the central neuroendocrine system responsible for coordinating stress responses through the release of corticotropin-releasing hormone (CRH), adrenocorticotropic hormone (ACTH), and cortisol (corticosterone in animals) (69)

Future strategies should emphasize precision-based interventions, including genotype-guided therapy and risk stratification, to effectively target HHcy and mitigate multi-organ disease progression

5c), whereas H 2 S did not facilitate any cyt c reduction (Extended Data Fig