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When either of the selective COX-inhibitors were applied before NPW treatment, a moderate degeneration in mucous cells and moderate degeneration in glandular cells, inflammatory cell infiltration and submucosal edema were identified

However, this needs to be tested specifically in spondyloarthritis ( 4 Potential association between DNA methylation and AS treatment 4.1 Methylation modifications affect drug response Epigenetic modifications, especially DNA methylation, have become significant regulators of gene expression that may affect drug response in AS ( Likewise, the methylation of absent in melanoma 2 (AIM2), a gene implicated in inflammasome activation and the production of inflammatory cytokines, has been associated with varying responses to anti-TNF- therapy in patients with AS

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Chromatographic separation was achieved using the following conditions: buffer A was 20mM ammonium carbonate, 0.1% ammonium hydroxide