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Metabolic changes during degeneration increase ROS production and impair mitochondrial function, causing mitochondrial fragmentation and apoptosis in NPCs (Figure 2)

Guanine's N7 position is exposed in the major groove of double-helical DNA, making it more suitable for adduction than when compared to adenine's N3 position, which is orientated in the minor groove

This cellular architecture enables them to respond to pathogen-associated molecular patterns through transcription and translation, thereby conferring immunocompetence

The means of different groups were compared using the Student (t) test