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SKU: 92318433812
Price: 24.48 USD
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Acidosis is due to reduced feedback inhibition of -glutamyl cysteine synthetase in the gamma-glutamyl cycle, which ultimately leads to overproduction and accumulation of 5-oxoproline

Additionally, macrophages depleted of Tet2 secreted more IL-1 upon stimulation with MSU crystals, a phenomenon mitigated by the inhibition of NLRP3 inflammasomes