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However, a major challenge in identifying beneficial drug interactions in the context of ageing is that a large number of possible combinations to be screened and the fact that lifespan studies, even in model organisms, are time consuming and expensive

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Furthermore, the regulation of Wnt signaling not only affects stem cell proliferation but also directs the differentiation of epithelial cells, maintaining the balance of various cell types, such as goblet cells and enteroendocrine cells, thereby preserving the integrity of the intestinal barrier [392]

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