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16, 21 Therefore, we have undertaken extensive studies to determine the potential for BSO to enhance the anti-myeloma activity of L-PAM at clinically achievable doses using in vitro (cell lines and fresh MM explants) and in vivo MM xenografts to determine if BSO+L-PAM warrants clinical trials in MM

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Paralleling the emerging role of ferroptosis in fungal infections, ferroptosis has also been implicated in parasitic infections, where parasites exploit host iron metabolism and lipid peroxidation pathways to modulate cell death

For instance, studies such as one on osteoarthritis (Jeon et al., 2017) have noted the re-emergence of senescent cells post-treatment cessation

79 Immune cells from people with fibromyalgia have demonstrated signs of mitochondrial dysfunction including low CoQ10 levels, increased oxidative stress, reduced mitochondrial capacity to generate energy, and increased removal of dysfunctional mitochondria