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Intriguingly, the phenotypes obtained by most investigators using iPSC-derived neurons from donors with SCZ show reduced dendritic spine and reduced synaptic functions, hinting to a neurodevelopment-related impairment (Figure 1)

Schizophrenia induces oxidative stress and cytochrome C release in isolated rat brain mitochondria: a possible pathway for induction of apoptosis and neurodegeneration

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14 In fact, dry eye syndrome can produce a vicious cycle in which poor tear production leads to inflammation that damages the eye surface and tear glands, leading to further loss of tear production and further damage