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4-) Stephens FB1, Marimuthu K, Cheng Y, Patel N, Constantin D, Simpson EJ, Greenhaff PL

Collectively, five independent reports converge on a common protective motif

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The nanomodulators could trigger an abrupt surge in mitochondrial Ca 2+ ions and rapidly cause mitochondrial Ca 2+ overload, contributing to ROS increasement, cytochrome C secretion, caspase-3 protein activation, GSDME cleavage, and eventually the tumor cells pyroptosis