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Zhong et al., 2006), glucose metabolism (Totary-Jain et al., 2005), lipoproteins (Srivastava et al., 1992), hypoxia (Fieber et al., 2006

doi:10.1200/jco.2008.21.6895 Acknowledgments This work was supported by US National Institutes of Health grants R01NS052634, 2T32NS048039, and T32GM008361

It not only enhances mitochondrial function in skeletal muscle and other organs, increases mitochondrial content, boosts the transcriptional activity of related proteins, and reduces the production of ROS, but also improves metabolic flexibilityall of these effects lay a solid physiological foundation for the core goal of cognitive prehabilitation, which is to preserve cognitive health

Ascioti AJ, Hofstetter WL, Miller MJ, Rice DC , Swisher SG, Vaporciyan AA, Roth JA, Putnam JB, Smythe WR, Feig BW, Mansfield PF, Pisters PW, Torres MT, Walsh GL