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Multiple binding sites in fibrinogen for integrin alphaMbeta2 (Mac-1)

Different from other classical cell death programs such as necrosis and apoptosis, ferroptosis involving iron-catalyzed lipid peroxidation is characterized by Fe 2+ accumulation and mitochondria alterations

Significant reductions in both LPS-induced nitric oxide production and inducible nitric oxide synthase expression were observed when 6-shogaol, 1-dehydro-10-gingerdione, and 10-gingerdione were applied (229)

These findings indicated that CUR/miR155@DssD-Hb NPs could stimulate ROS generation mediated by CUR as a ROS initiator in tumor cells, potentially hastening nanoparticle disintegration and CUR release, thereby establishing a positive feedback loop to bolster antitumor efficacy