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Similarly, in ex situ organ perfusion (ESOP) (60), the absence of the biological role of organs, such as the liver, leads to the inability to scavenge oxygen radicals generated by oxidative stress, thus making such a technique more challenging compared with physiological conditions ( 4.3 Endogenous and exogenous coagulation systems Under normal physiological conditions, coagulation mechanisms include both coagulation and anticoagulation, and the dynamic balance between them plays a key role in maintaining normal blood flow and preventing coagulation (61)

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The pharmaceutical substance according to a therapeutic dose of a vicinal dimercaptan or dithiol such as DMPS or DMSA

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Until now the tests with exendin-4 had only been done in mice and the company was unsure what would happen when it was given to humans