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In addition, transgenic mice that express human catalase targeted to the mitochondria exhibited less severity of age-related OA compared to WT mice [143]

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doi: 10.1007/s00284-011-9915-3 229 ZilmerMSoometsURehemaALangelU

Notably, individuals with IBD show a depletion of butyrate-producing bacteria and diminished colonic butyrate concentrations compared to healthy controls, underscoring the immunomodulatory potential of butyrate (Hodgkinson et al., 2023)