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67 Skin cells express these G protein-coupled seven-transmembrane tethered ER, termed GPER and are also known as GPER1 or GPR30 (Figure 3A)

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Interestingly, the reversal of the FXN gene silencing in neurons derived from patient iPSCs is comparable to that found in previous studies performed on PBMCs and in vivo models [55,56,57,58]