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But it also regulates the immune response, for example in the production of cytokinesCytokines are small proteins produced by the immune system, which bind to specific receptors present on the cell membrane and communicate to the cell a specific set of instructions such as, for example, the stimulus to grow, or to differentiate or even the order to die

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Transition metalbased carriers (e.g., MnO, Cu 2 , Fe 3 ) provide an additional layer of functionality, as they can both deplete intracellular GSH and generate reactive oxygen species, thereby amplifying oxidative stress within tumors

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Plant alkaloids such as berberine carried out the inhibition of NADPH oxidase activity via reducing the mRNA expression of gp91phox in macrophages