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Using a yeast interaction network (The Cell Map 27 ), we identified GSH1 and GSH2 (yeast glutamylcysteine ligase and glutathione synthetase, respectively) as two of the highest scoring synthetic lethal interactions of mtm1, the S.cereviase ortholog for SLC25A39 (p-value=2.78E-28 (GSH1)

These selectivity pharmacology studies have established Ipamorelins pentapeptide structure as the reference pharmacophore solution for achieving GHS-R1a-selective GH release and provided the comparative dataset against which all subsequent selective GH secretagogue compounds are evaluated