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Its delayed inhibitory effect on cellular function and high accumulation in lysosomes are frequently accompanied by disruption of protein and intracellular lipid transport, modulation of surface receptor expression, altered macrophage phenotype, and impaired autophagy (213)

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(iii) Metformin may interfere with the reabsorption of bile acids in the enterohepatic circulation because some B 12 is excreted in bile and may not be reabsorbed under this condition [26]

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At 12 months, those in the vitamin D group had significantly greater improvements in overall cognitive function, as measured with a variety of tests assessing memory, attention, and processing