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For example, topical cholesterol tends to protect barrier-disrupted skin from UV damage, while linoleic acid (-6 polyunsaturated fat) aggravates UV damage

Evidence that the enzymes themselves can be modified by redox-related processes such as S -nitrosylation (Romero-Puertas and Sandalio 2016), in addition to the transcriptional control of the genes encoding them, emphasizes the intricacy of the checks and balances operating to maintain redox homeostasis within the cellular environment

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Until such evidence becomes available, mitochondriaorganelle crosstalk should be regarded as a strong integrative framework for AP pathobiology, but not yet as a fully validated map of causal hierarchy in human disease

Nature 583 578584