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Pyroptosis exacerbates immune dysfunction by recruiting activated immune cells, including macrophages, neutrophils, central memory CD8+ T cells, and Tregs with unregulated chemokines (96)

Additionally, NK cells facilitate DC antigen presentation by inducing apoptosis in target cell and releasing intracellular antigens, which promotes T cell activation

Pubmed Jones BW, CB Watt, JM Frederick, W Baehr, CK Chen, EM Levine, AH Milam, MM LaVail, RE Marc 2003 Retinal remodeling triggered by photoreceptor degenerations

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Abstract Neurodegenerative diseases are increasingly significant causes of mortality and morbidity worldwide, particularly among the elderly