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Advances in pharmacological inhibitors, iron chelators, lipid metabolism modulators, and GPX4-targeted interventions highlight the translational potential of ferroptosis research (207)

Elevated ghrelin alters the behavioral effects of perinatal acetaminophen exposure in rats

It is largely initiated by extra-mitochondrial lipid peroxidation occurring from an iron-dependent ROS accumulation, caused by abnormal iron metabolism or disturbances in the main redox systems, lipid peroxidation, and thiols, in particular GSH [30]

The three studies highlighted in this section utilize Cu 2+ /Cu + redox reactions to elevate O 2 levels and lower reductive GSH levels ( Figure 5A ) (155), Mn 4+ /Mn 2+ redox reactions to increase O 2 levels and decrease GSH levels ( Figure 5B ) (166), and the cycling between Cu 2+ and Cu + ions to regulate H 2 O 2 and GSH levels along with hydroxyl radical concentrations ( Figure 5C ) (167)