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A.Hormozi-NezhadM

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Shankland, EG

Mechanistically, GLPs exert renoprotective effects by suppressing the PI3K/Akt/mTOR signaling cascade, promoting autophagicevidenced by increased Beclin-1 expression and LC3-II/LC3-I ratio, along with decreased p62 accumulationwhile simultaneously attenuating apoptotic activity (reducing caspase-3 and caspase-9 levels) and dampening pro-inflammatory responses (lowering IL-6, IL-1, and TNF-)