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For patients with relapsing disease, immunosuppressive medications for prevention of graft versus host disease (GVHD) can be rapidly tapered, thereby engendering enhanced donor immune activation, primarily T cell alloreactivity

Simultaneously, the activation of the PI3K/Akt pathway leads to the phosphorylation and activation of endothelial Nitric Oxide Synthase (eNOS)

PMID: 38718067, PMCID: PMC11078344, DOI: 10.1371/journal.pone.0299533

Current knowledge about the underlying mechanisms of reductive stress and its biological consequences as well as how cells respond to reductive stress remains limited

[DOI] [Google Scholar] 68.Whittinghill J.M., Norton J., Proctor A