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[DOI] [PMC free article] [PubMed] [Google Scholar] 15.ESPOSITO B P, BREUER W

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This may trigger caspase-dependent apoptosis either directly via caspase-3 processing and/or indirectly, through BH3-only protein Bid cleavage and the mitochondria-dependent signaling (Gupta, 2003)

Extending those mechanisms to human aging remains an open research question, not an established result

Trends Neurosci 32(3):160169 Faissner A, Pyka M, Geissler M et al (2010) Contributions of astrocytes to synapse formation and maturation potential functions of the perisynaptic extracellular matrix