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In PD, astrocytes undergo reactive metamorphosis (A1 phenotype), producing S100, GFAP, and chemokines such CCL2 and CXCL10, which promote leukocyte recruitment and neuroinflammation [75]

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193, 194, 195 Treatment with either azaserine or DON decreased protein O -GlcNAcylation level, reduced -catenin expression and reversed glucose-mediated cell proliferation

3 capsules per serving to receive 1,000mg of NAC with 50mg of glutathione in its most active reduced state