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359 Shikonins dual inhibition of TRXR and PKM2 induces necroptosis, whereas Nrf2 hyperactivation mediates resistance, which can be reversed through metabolic targeting

No tolerance developed to this protective effect, which appeared to be mediated by (1) the activation of 5-HT 1A receptors, as it was antagonized by the administration of WAY100635 30 min before stress exposure

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13,28 In fact, the average time between seeking care and getting a fibromyalgia diagnosis has been reported to be 2.7 years

doi: 10.1017/S0954422420000074 18 ToVMasagounderKLoewenME