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In vitro binding [13] and crystal structure analyses [13, 39,40,41,42,43] suggest that most of DUSPs (except DUSP2, DUSP6, DUSP7, DUSP9, DUSP24, and DSUP29) contain an adjacent pocket, which cooperates with the catalytic pocket to interact with double-phosphorylated T-X-Y motifs of MAPKs

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In general, metabolic reprogramming is of great significance in finding the key points for the treatment of platinum-resistant relapse

A decrease in GSH: GSSG ratio indicating increased oxidative stress was observed in BT12 and G401 cell lines

Researchers believe that the excessive release of histamine from mast cells in the early morning hours is due to a disrupted circadian rhythm