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In this context, the review identifies four fundamental design principles, offering a clear roadmap for future research ( Figure 3 )

Dar GM, Agarwal S, Kumar A, Nimisha, Apurva, Sharma AK, et al

it is also a major NAD + consumer with a lower K m than most NAD + -consuming enzymes 40 and is implicated in the decline of NAD + levels observed during aging and disease 50,51,52

(2024), a prebiotic serves as nourishment for the beneficial bacteria in the hosts digestive tract, whether in the form of a substance, substrate, long-chain sugar, vitamin, or fiber

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