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Necroptosis deficiency significantly reduced the number of Ly6G + PMN and CD68 + macrophages within the tunica media and was associated with an improved number of SMCs compared to WT aneurysms, which showed significant loss of SMC population in tunica media identified by the loss of SMA signal

Therefore, while the enhanced functions of ATP5F1B and COX4I2 support cellular metabolism under normal conditions, in the pathological state of diabetes and especially DKA, they might intensify metabolic stress and cellular stress responses

doi: 10.1080/09687680802650481 143 KabouridisPSMageeAILeySC

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the cytosol and mitochondrial matrix have high GSH:GSSG ratios of approximately 100:1, whereas the ER has a substantially lower ratio of closer to 3:1 (Forman et al., 2009