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Therapeutic potential of superoxide dismutase mimetics as therapeutic agents in critical care medicine

4.13.2 Mechanical stress Mechanical testing demonstrates increased tissue stiffness that limits adipocyte expansion and triggers mechanotransduction through focal adhesion complexes (327, 328)

10.1002/minf.201400134 12 BakerE

These increase methylation demand and interfere with folate metabolism

Live imaging microscopy of adipocytes transduced with an Akt sensor (FoxO1-Clover) demonstrated that FoxO1 translocation from the nucleus to the cytosol was reduced, indicting less Akt activation in Mg 2+ -deficient adipocytes