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Retinol activates nuclear retinoic acid receptors and drives collagen gene transcription, but frequently causes irritation, peeling, and photosensitivity at therapeutic concentrations

Vitamin B12 (cobalamin) is a water-soluble vitamin required for DNA synthesis, red blood cell formation, myelin maintenance, and methylation the biochemical process that regulates gene expression, neurotransmitter production, and homocysteine metabolism

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