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In this DIC model, weight loss, representing emaciation relevant to DOX treatment, was not observed (Figure 1C)

doi: 10.1146/annurev-animal-021419-083952 240 OharaA

10.4049/jimmunol.157.10.4568 93

Furthermore, a metabolic profiling study of 200 ME/CFS patients identified diminished serum amino acids essential for oxidative metabolism, alongside elevated expression of pyruvate dehydrogenase kinases (PDKs) in PBMCs, which inhibited pyruvate dehydrogenase (PDH)

Regarding the interplay between oxidative stress and inflammation, which forms a 'vicious cycle' (51), combined antioxidant and anti-inflammatory therapy strategies are considered more advantageous (132)