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Description

PMID: 32766800

Epub 2012/09/22

The failure of proteostasis mechanisms under metabolic stress contributes to the accumulation of misfolded proteins, defective organelles, and disrupted signaling pathways, thereby amplifying metabolic dysfunction and tissue damage (Fig

Our aim was to develop a representative in vitro model of HT1 using human induced pluripotent stem cell (iPSC) and assess the effect of NTBC treatment