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In order to delineate the role of THO in the pathogenesis of DED, in this review article, we summarize current knowledge related to the molecular mechanisms responsible for the development of THO-induced pathological changes in the eyes of DED patients, and we briefly discuss the therapeutic potential of hypo-osmotic eye drops in DED treatment

Effects of apolipoprotein B on lifespan and risks of major diseases including type 2 diabetes: a Mendelian randomisation analysis using outcomes in first-degree relatives